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Table 2 21del analysis of lineages representing the LCC and Haarlem groups

From: Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region

Group/Lineage Same cluster Different clusters Total Standard genotype Mutations observed
LCC, 2 banders 4 N.A. 4 2, WT/21del 0
LCC, 3 banders 6 N.A. 6 2, WT/21del 1. (1, 21del)
LCC, 4 banders 6 N.A. 6 2, WT/21del 0
LCC, 5 banders 6 N.A. 6 2, WT/21del 1. (1, WT)
LCC, 6 banders 4 N.A. 4 2, WT/21del 0
F6. Haarlem-like 3 3 6 1, 21del 0
F7. Haarlem-like 3 5 8 1, 21del 0
F1. Haarlem - 3 3 2, WT/21del 0
F2. Haarlem 5 8 13 2, WT/21del 1. (1, 21del)
F4. Haarlem 4 6 10 1, WT 0
F10. Haarlem 4 2 6 1, 21del 0
F24, Pre-Haarlem 4 5 9 1, WT 2. (2, WT/21del)
F19, Pre-Haarlem 4 5 9 2, WT 0
Total 53 36 90   5
  1. N.A.: Not applicable. Because of the invariance of the IS6110 RFLP patterns LCC lineages cannot be subdivided into clusters.
  2. The "1, 21del" genotype observed in these lineages is due to deletion of the 3' end of PPE38 by an IS6110-mediated mechanism rather than homologous recombination with deletion of PPE38.