The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes

Table 1 Model parameters.

symbol	meaning	values
N ₀	initial size of population	10², 10⁴, 10⁶
L	size of mutant neighborhood (number of accessible 1-step mutants)	5, 50, 500
r	fraction of mutant neighborhood that is changed (ruggedness of fitness landscape)	0.1, 0.5, 1
μ	beneficial mutation rate per replication	10^-6
D	number of divisions per growth cycle	10
α	distribution of fitness effects	30

Beneficial mutation rate, divisions per growth cycle and distribution of fitness effects were chosen in line with values reported in [16,14] and [20] respectively. The other parameters were chosen to explore the evolution of populations for a wide range of scenarios, as described in detail in the main text.

ISSN: 2730-7182