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Table 4 Grantham's distance for GluR genes using human-specific "fixed" amino acid substitutions

From: The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family

Gene

Number of substitutions

Total Grantham's distance

Substitutions

(Amino acid position, Grantham's distance)

GRIN2C

5

476

(89, 29) (100, 94) (596, 99) (933, 74) (1221, 180)

GRIN3A

6

438

(30, 56) (71, 94) (121, 58) (885, 99) (988, 29) (1059, 102)

GRM6

3

230

(612, 83) (714, 21) (877, 126)

GRIK5

2

127

(298, 98) (809, 29)

GRIN2A

3

125

(906, 46) (1006, 64) (1221, 15)

GRIA4

1

112

(5, 112)

GRID1

2

102

(295, 81) (628, 21)

GRIN3B

3

98

(468, 64) (499, 5) (727, 29)

GRM2

1

60

(6, 60)

GRM8

1

29

(653, 29)

GRM7

1

27

(520, 27)

Total

28

1824

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