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Table 1 Pairwise comparison of functional divergence of mouse oocyte-expressed Nlrp genes

From: Evolution and functional divergence of NLRPgenes in mammalian reproductive systems

Gene cluster MFE θ MLE θ p value RFD No. Cutoff
Nlrp4/9 0.65 ± 0.07 0.61 ± 0.05 < 0.0001 91 0.78
Nlrp4/14 0.96 ± 0.08 0.89 ± 0.06 < 0.0001 118 0.94
Nlrp4/5 0.68 ± 0.08 0.67 ± 0.06 < 0.0001 61 0.84
Nlrp9/14 0.76 ± 0.08 0.65 ± 0.06 < 0.0001 59 0.80
Nlrp5/9 0.64 ± 0.09 0.58 ± 0.07 < 0.0001 53 0.75
Nlrp5/14 0.49 ± 0.10 0.45 ± 0.07 < 0.0001 33 0.70
  1. θ, coefficient of functional divergence; MFE, Model-Free Method; MLE, Maximum-Likelihood Estimation under two-state model; p value, significance level calculated by the method of Fisher's transformation on z scale, and from chi square on LRT; RFD No., number of residues with predicted functional divergence;-cutoff, the minimal posterior probability for amino acids causing functional divergence, established empirically by progressively removing the highest scoring residues from the alignment until θ dropped to zero.