Skip to main content

Table 1 Pairwise comparison of functional divergence of mouse oocyte-expressed Nlrp genes

From: Evolution and functional divergence of NLRPgenes in mammalian reproductive systems

Gene cluster

MFE θ

MLE θ

p value

RFD No.

Cutoff

Nlrp4/9

0.65 ± 0.07

0.61 ± 0.05

< 0.0001

91

0.78

Nlrp4/14

0.96 ± 0.08

0.89 ± 0.06

< 0.0001

118

0.94

Nlrp4/5

0.68 ± 0.08

0.67 ± 0.06

< 0.0001

61

0.84

Nlrp9/14

0.76 ± 0.08

0.65 ± 0.06

< 0.0001

59

0.80

Nlrp5/9

0.64 ± 0.09

0.58 ± 0.07

< 0.0001

53

0.75

Nlrp5/14

0.49 ± 0.10

0.45 ± 0.07

< 0.0001

33

0.70

  1. θ, coefficient of functional divergence; MFE, Model-Free Method; MLE, Maximum-Likelihood Estimation under two-state model; p value, significance level calculated by the method of Fisher's transformation on z scale, and from chi square on LRT; RFD No., number of residues with predicted functional divergence;-cutoff, the minimal posterior probability for amino acids causing functional divergence, established empirically by progressively removing the highest scoring residues from the alignment until θ dropped to zero.