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Figure 1 | BMC Evolutionary Biology

Figure 1

From: The distribution of CTL epitopes in HIV-1 appears to be random, and similar to that of other proteomes

Figure 1

Schematic of the MHC-pathway model. A window of 14 amino acids is slided across a protein. Each of these '14 mers' consist of a N-terminal flanking region of 1 amino acid, a 9 mer epitope candidate and a C-terminal flanking region of 4 amino acids. Beneath the 14 mer, the parts of the peptide are marked which are used by the MHC, TAP or proteasome predictors. Applying the 14 mer to the MHC, TAP and proteasome predictors results in three different scores. Only if each of these scores is higher than a fixed threshold, the epitope candidate is predicted to be a CTL epitope for the MHC allele under consideration.

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