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Figure 4 | BMC Evolutionary Biology

Figure 4

From: A P2X receptor from the tardigrade species Hypsibius dujardiniwith fast kinetics and sensitivity to zinc and copper

Figure 4

Hd P2X is antagonised by suramin and PPADS. The effects of the P2 receptor antagonists suramin and PPADS were determined in Xenopus oocytes expressing HdP2X at a holding membrane potential of -60 mV. A. Example currents in response to 100 μM ATP in the presence and absence of 100 μM suramin (five minutes between sequential applications). B. Example currents in response to 100 μM ATP in the presence and absence of 100 μM PPADS (five minutes between sequential applications). C. Inhibition curves for mean responses to 100 μM ATP in the presence of suramin (closed squares) (n = 5) and PPADS (open circles) (n = 5).

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