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Table 3 Frequencies and predicted functional impacts of chicken nonsynonymous SNPs on the IL-4Rα protein product compared to the red JF genome sequence

From: Evidence of balanced diversity at the chicken interleukin 4 receptor alpha chain locus

Base Positions Amino Acid Prediction Score Certainty N2 Outcome
  Position Red JF M.A.      
4435–37 5 F L neutral 0.316 3 111 not significant
4450–52 10 T A neutral 0.104 7 1 neutral
9622–24 138 N H neutral 0.320 3 1 not significant
12661–63 520 L P neutral 0.413 1 102 not significant
12871–73 590 S G neutral 0.329 3 173 not significant
12883–85 594 L R neutral 0.270 4 174 not significant
13096–98 665 M R neutral 0.495 0 172 not significant
13096–98 665 M Q neutral 0.119 7 7 neutral
13096–98 6651 R Q neutral 0.510 5 7 not significant
13096–98 6651 R stop - - - 1 deleterious
13111–13 670 S Y neutral 0.036 9 163 neutral
13111–13 670 S F neutral 0.061 8 17 neutral
13111–13 6701 Y F neutral 0.023 9 17 neutral
13177–79 692 T S neutral 0.037 9 157 neutral
13177–79 692 T N neutral 0.060 8 23 neutral
13177–79 6921 S N neutral 0.028 9 23 neutral
  1. M.A. is the minor allele(s), in some cases this is the most frequent in the chicken samples. Amino acid sites 5, 10, 524 and 669 are polymorphic in the outgroup samples as well. 1 Polymorphic within chicken samples only. 2 N is the number of observed samples with the M.A. Substitutions where the PMut certainty values ≤ 6 did not have statistical support for the predicted change.