Figure 2

Comparison of SPFH1,2 and 5 subgroup members. Partial alignment and secondary structure annotation between SPFH1,2 and 5, using the already known 3D structure of Flotillin2 (PDB ID: 1WIN). The alignment of the SPFH domains of different SPFH1,2 and SPFH5 members reveals a continuum of similarity between both groups, suggesting that SPFH5 members belong to the SPFH superfamily.