Molecular evolution and functional divergence of the bestrophin protein family

Table 3 Functional divergence estimated in 53 vertebrate bestrophin paralogues

Comparison	θ^a	SE^b(θ)	LRT^c (θ)	P^d	Probability cutoff^e
Best1 vs Best2	0.097	0.076	1.640	0.024541	-
Best1 vs Best3	0.142	0.043	10.762	0.000488	-
Best1 vs Best4	0.217	0.039	30.099	8.88557e-8	0.70
Best2 vs Best3	0.380	0.073	27.152	6.32074e-9	0.80
Best2 vs Best4	0.320	0.075	18.120	9.855e-10	0.64
Best3 vs Best4	0.260	0.059	19.338	9.477e-10	0.70

^a θ is the coefficient of functional divergence.
^b SE, standard error.
^c LRT (θ) is a likelihood ratio test.
^d significance level (P^c) calculated by the method of Fisher's transformation and corrected by Bonferroni.
^e Probability cut-off is the minimal posterior probaility for amino acids causing functional divergence.

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