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Table 2 Likelihood values and parameter estimates for the vertebrate bestrophin genes

From: Molecular evolution and functional divergence of the bestrophin protein family

Model

dN/dSa

Estimates of parametersb

l

Positively Selected Sitesc

M0 (one-ratio)

0.053

ω = 0.053

-22547.97

not allowed

M1a (nearly neutral)

0.084

p0 = 0.964, (p1 = 0.036)

(ω0 = 0.050), (ω1 = 1)

-22443.90

not allowed

M2a (positive selection)

0.084

p0 = 0.964, p1 = 0.002, (p2 = 0.033)

(ω0 = 0.050), (ω1 = 1), ω2 = 1

-22443.90

not found

M3 (discrete)

0.058

p0= 0.529, p1= 0.355, (p2 = 0.115)

ω0 = 0.011, ω1 = 0.073, ω2 = 0.230

-22016.13

not found

M7 (beta)

0.063

p = 0.598, q = 8.411

-22007.24

not allowed

M8 (beta&ω)

0.220

p0= 1, (p1 = 0)

p = 0.685, q = 1.988, ω = 4.997

-19662.03

8, 25, 40, 41, 42, 44, 45*, 48, 49, 52*, 53, 55, 56, 57, 60*, 61*, 67, 71, 95, 108, 113, 117, 120, 154, 159, 165*, 170, 173, 175, 193, 197, 207*, 209*, 216, 219, 261, 263*, 265*, 331*, 340, 341, 342, 344, 354*

  1. a The dN/dS ratio is an average over all sites of bestrophin gene alignments.
  2. b Parameters in parentheses are not free parameters.
  3. c Numbering of amino acid residues corresponds to human bestrophin 1. Positive selection sites with posterior probabilities > 95% are shown in bold.
  4. * The amino acid residues depicted with an asterisk were also found to be implicated in the functional divergence between bestrophin paralogues (see Table 4).