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Table 2 Likelihood values and parameter estimates for the vertebrate bestrophin genes

From: Molecular evolution and functional divergence of the bestrophin protein family

Model dN/dSa Estimates of parametersb l Positively Selected Sitesc
M0 (one-ratio) 0.053 ω = 0.053 -22547.97 not allowed
M1a (nearly neutral) 0.084 p0 = 0.964, (p1 = 0.036)
0 = 0.050), (ω1 = 1)
-22443.90 not allowed
M2a (positive selection) 0.084 p0 = 0.964, p1 = 0.002, (p2 = 0.033)
0 = 0.050), (ω1 = 1), ω2 = 1
-22443.90 not found
M3 (discrete) 0.058 p0= 0.529, p1= 0.355, (p2 = 0.115)
ω0 = 0.011, ω1 = 0.073, ω2 = 0.230
-22016.13 not found
M7 (beta) 0.063 p = 0.598, q = 8.411 -22007.24 not allowed
M8 (beta&ω) 0.220 p0= 1, (p1 = 0)
p = 0.685, q = 1.988, ω = 4.997
-19662.03 8, 25, 40, 41, 42, 44, 45*, 48, 49, 52*, 53, 55, 56, 57, 60*, 61*, 67, 71, 95, 108, 113, 117, 120, 154, 159, 165*, 170, 173, 175, 193, 197, 207*, 209*, 216, 219, 261, 263*, 265*, 331*, 340, 341, 342, 344, 354*
  1. a The dN/dS ratio is an average over all sites of bestrophin gene alignments.
  2. b Parameters in parentheses are not free parameters.
  3. c Numbering of amino acid residues corresponds to human bestrophin 1. Positive selection sites with posterior probabilities > 95% are shown in bold.
  4. * The amino acid residues depicted with an asterisk were also found to be implicated in the functional divergence between bestrophin paralogues (see Table 4).