Figure 4

Amino acid sequence conservation in the fish s100 gene repertoire. Conservation is displayed as a sequence logo. In this representation, the relative frequency with which an amino acid appears at a given position is reflected by the height of its one-letter amino acid code in the logo, with the total height at a given position proportional to the level of sequence conservation. The regions corresponding to the Helices (H), the S100 EF Hand Calcium-binding domain, the Hinge and the Calcium-binding domain of the canonical EF Hand are numbered and indicated. Sequence alignments were manually edited (for details see Methods section).