Figure 1

Phylogenetic tree of the teleost and human s100 gene family. A) 85 fish S100 (bony fishes in red and cartilaginous fishes in orange), 10 lamprey S100 (light-green) with human s100 genes (full set, excluding close relatives [38], light blue) and several representatives of another EF hand family, the troponins as an outgroup (black). B) Fish s100 genes from six teleost species and two cartilaginous fish (Squalus acanthias and Callorhinchus milii) are depicted. Catfish S100I [18] groups with zebrafish S100I (not shown). The Tn_S100T fragment (2nd exon, see Additional File 4) is not included for technical reasons. The colored names indicate fish s100 genes previously published. Stars indicate that the clades downstream of the node are supported by all three methods used for the phylogenetic analysis (NJ, ML and MP). The trees presented were constructed using the NJ method. Bootstrap support (total 10000 replications) is indicated at the major nodes. Scale bar indicates the number of amino acid substitution per site.