Figure 2

Schematic diagram depicting the deduced protein structures of zebrafish NLRs. Zebrafish NLR subfamily-A have structures similar to the NOD subfamily in mammals, with NOD1/NLR-A1 possessing one CARD motif while NOD2/NLR-A2 possesses two. While only the NACHT domain was identified for most members of the NLR-B subfamily, one member of this group (NLR-B2) was predicted with a putative N-terminal CARD effector domain. All NLR-C subfamily members were predicted to have an N-terminal effector domain, a central NACHT domain and a LRR domain. In addition, some of the NLR-C molecules were identified with a C-terminal B30.2 domain. The predicted effector domains of molecules within the NLR-C subfamily varied; some had a pyrin (P) effector domain, while others had a distinct uncharacterized effector domain (X). B30.2 domains are also found in other important immune related molecules such as certain TRIMs and the Pyrin molecule, whose structures are also shown. C = card domain, P = pyrin domain, X = other domain, N = NACHT domain, L = LRR region, B = B30.2/PRY-SPRY domain, R = ring finger domain, BB = B-box, CC = coiled coil.