Figure 1

Phylogeny of the Otopetrin Domain Protein (ODP) family. Maximum-likelihood phylogenetic tree created from the multi-sequence alignment of 62 ODPs (see additional file 1). The vertebrate, arthropod, and nematode sequences form distinct monophyletic groups, each containing three or more paralogous groups. Some nematode and arthropod sequences appear to have undergone additional gene-duplication events, creating species-specific paralogs (designated with a 1 or 2 following the gene symbol). Branch labels are bootstrap values for 1000 replicates. Unlabeled internal branches have bootstrap values less than 90.0.