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Figure 6 | BMC Evolutionary Biology

Figure 6

From: The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?

Figure 6

Location of mutations in the 3D structure of the androgen receptors. Cubic view of localization of the substitutions onto the surface representation of the LBD of the human AR (1XNN.pdb). (Top): number of substitutions characterizing CAIS, PAIS + MAIS, and the prostate cancer. The mutations are those listed in Additional file 6. Amino acid changes (regardless of the kind of substitutions) can lead to different phenotypes: e.g. 5 is the number of aa found in CAIS in a patient, and prostate cancer in another; 9 is the sum of 5 aa reported as found in both PAIS and prostate cancer, etc... See details in Additional file 7. Color codes are reported in the 3D structure. (Bottom): Localization of the substitutions characterizing AR-A and AR-B in fish compared to all other AR. There are 14 identical substitutions in the 2 ARs (that are found in fish AR but not in other vertebrates). We found respectively 14 and 38 substitutions in AR-A and AR-B, 9 of them being common with different substitutions in these two ARs (in green). Color codes are reported onto the 3D representation.

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