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Figure 5 | BMC Evolutionary Biology

Figure 5

From: Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis

Figure 5

Diagrammatic depiction of separate NPS2 (A) and NPS1/SidC (B) lineage AMP and CON domain trees. (i) and (ii) are ML and Bayesian analyses, respectively. A. Relationships among A and among C domains in the NPS2 lineage. As demonstrated in the full A domain dataset analyses (Fig. 3, see Additional files 3 and 6), both NPS2 lineage A analyses support a relationship between C-terminal modules 3 or 4 and module 2, and a relationship between N-terminal module 1 and Dothideomycete module D.3. For the C trees, both analyses support a relationship between C4, and C6 (bs = 89% and pp = .76) and between C3 and C5 (bs = 68% and pp = 1.00). C2 groups with C4 and 6 in the ML analysis and with C3-6 in the Bayesian analysis but without support in either case. In both trees, C1 is ancestral, but without support. B. Relationships among A and among C domains in the NPS1/SidC lineage. As demonstrated in the full A domain analyses (Fig. 3, see Additional files 3 and 6), both NPS1/SidC lineage A domain analyses support a relationship between N-terminal module 1 and module 2, and indicate C-terminal module 3 is ancestral. Similarly, the ML and Bayesian trees support a close relationship between the C domains of modules 1 and 2.

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