Table 1 List of core NCLDV genes with cellular homologs and their corresponding phylogenetic status.
Core NCLDV genes | Phylogenetic status of the NCLDVs sequences | Remarks |
|---|---|---|
DNA Polymerase B | Basal | |
A18-type helicase | Basal | |
Thiol-Oxydoreductase | Basal | |
Ser/Thr Kinase | LGT for CIV iridovirus and vertebrate Poxviruses | |
PCNA | Basal | |
RNR small ssu | LGT for Trichoplusia Ascovirus and mammalian Poxviruses | |
RNR large ssu | LGT for mammalian Poxviruses | |
Thymidilate kinase | LGT for CIV iridovirus and vertebrate Poxviruses | |
Thymidilate synthase ThyA-type | Polyphyletic | Probable displacement of this enzyme in the Chlorella Phycodnavirus by bacterial thymidilate synthase ThyX-type |
β-clip dUTPase | LGT for Orf Poxviruses, Entomopoxviruses, and Chlorella Phycodnaviruses | Probable displacement of this enzyme in the Mimivirus by a bacterial MazG dUTPase |
Capping Enzyme | Basal | |
ATP-dependant Ligase | LGT for phycodnavirus EHV86 and vertebrate Poxviruses | Probable displacement of the ancestral NAD dependant Ligase by this enzyme in EHV86 and Poxviruses |
RNA polymerase ssu 1 | Basal | |
RNA polymerase ssu 2 | Basal | |
Topoisomerase II | Basal | Probable displacement of this enzyme in the Mimivirus and Poxviruses by a bacterial Topoisomerase I |
RNA polymerase ssu 10 | Basal |