Figure 6

Protease comparisons between Ty3/Gypsy and Retroviridae LTR retroelements. Each Retroviridae PR isoform has one or more distant counterparts found among the variety of PR isoforms coded by Ty3/Gypsy LTR retroelements. A) Multiple alignment of class I and several Ty3/Gypsy lineages. This comparison reveals a similar, but not identical, flap sequence motif that in consensus defines an idealized GANG motif (logo above). B) Multiple alignment showing how the Micropia/Mdg3 clade and other Ty3/Gypsy LTR retroelements code for PRs harboring a GIGG flap variant almost identical to that of class II PRs. C) Multiple alignment between spumaretroviruses and errantiviruses showing how these 2 lineages commonly code for PRs bearing the TIHG variant.