The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

Table 4 Test for a recent change in allelic frequency based on the distribution of segregating sites between allelic classes.

Sample	Allelic class	Class Count^a	Sequenced Haplotypes^b	Observed Segregating sites^c
An. arabiensis (TED)	S & R	11 s \| 33 r	11 s \| 24 r	12 \| 12^#
An. gambiae 'Mbita' (TED)	S & R	32 s \| 13 r	27 s \| 12 r	10 \| 3^ns
An. gambiae 'Cameroon' (TED)	S & R conversion S & R	9 s \| 15 sr	9 s \| 15 sr	8 \| 0 *
An. arabiensis (all)	S & R	11 s \| 33 r	7 s \| 20 r	22 \| 23*
An. gambiae 'Mbita' (all)	S & R	32 s \| 13 r	19 s \| 10 r	35 \| 11^ns

^a The observed frequency of the TEP1s and TEP1r classes; ^b the number of haplotypes sequenced from each allelic class, ^c the total number of synonymous and non-synonymous segregating sites observed in that allelic class. Significance was assessed using simulations under a neutral model in which the frequency of each allelic class is constant, and proportional to the observed frequency (See main text, and Stahl et al 1999)
^nsp > 0.05; ^# p < 0.1; * p < 0.05,

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