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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Evolutionary analysis of the highly dynamic CHEK2duplicon in anthropoids

Figure 3

Comparative in silico analysis of CHEK2 duplicons in human and chimpanzee. Genomic structure of the CHEK2 duplicon family in the (A) human (NCBI Build36.2) and (B) chimpanzee (NCBI Build2) sequence assembly. The respective ancestral CHEK2 locus is depicted by the top horizontal red bar. Within each bar the corresponding accession numbers of the contigs and the position of the CHEK2 exons (green rectangles) and TTC28 exon (blue rectangle) are given. The precise genomic extension of the ancestral loci within each contig is shown beneath. The next two layers illustrate the common repeat and simple repeat content of the ancestral loci as black and grey boxes, respectively. All derivative duplicons are shown below using the indicated colour key. Precise positions of each derivative duplicon within the corresponding contig and the genomic extension of the sequence homology shared with the ancestral locus are indicated below and above each bar, respectively. Striped boxes represent LINE1 elements. LINE1 element integration-sites within the respective contigs are given below and the position of homology break within the ancestral locus is given above. Overall sequence identities between the paralogous human and chimpanzee CHEK2 duplicons and the respective ancestral CHEK2 sequences are given next to all CHEK2 duplicons.

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