Figure 2

Substitution rates at mutational equilibrium. Ratio of estimated to true CpG differences and estimated to true non-CpG differences as a function of increasing sequence divergence for phylogenies derived from randomly generated sequences evolved to be at mutational equilibrium. Results are shown for four different levels of hypermutability: no hypermutability, 5-fold, 10-fold and 20-fold hypermutability (a, b, c and d). Each line represents 50 data points, each of which was estimated from the evolution of a single, randomly-generated 3 Mb sequence.