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Figure 3 | BMC Evolutionary Biology

Figure 3

From: Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication

Figure 3

Amino acid sequence alignment of human AQP1 and teleost Aqp1a and Aqp1b. The six transmembrane (TM) domains and connecting loops A-B of human AQP1 are indicated by brackets and horizontal arrows, respectively. The vertical arrows above human AQP1 show the conserved residues Phe56, His180 and Arg195 (human AQP1 numbering) in water-selective AQPs. Identical residues between human AQP1 and teleost AQP1-like sequences are indicated with an asterisk, whereas conserved amino acid substitutions and substitutions with similar amino acids are indicated by a double or single dot, respectively. Residues conserved in human and most teleost sequences are shaded in black, and residues different from human but conserved between most of the teleost Aqp1a and Aqp1b sequences are shaded in grey.

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