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Table 3 Average chemical differences of amino acid changes

From: Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations

Gene Disease nsSNP Interspecific
HERG 93.63 (3.99)
n = 172
75.50 (10.55)
n = 16
67.37 (1.97) *
n = 296
KCNQ1 88.29 (3.75)
n = 174
52.25 (8.66) †
n = 12
58.32 (2.74) *
n = 168
  1. *, † indicate a significant difference from disease severity († p < 0.0001, *p < 0.008) as determined by a Mann-Whitney U test. There was no significant difference between the average chemical differences observed in disease vs. polymorphic changes (p = 0.218) for HERG. There was no significant difference between the average chemical differences observed in polymorphic and interspecific amino acid changes in either HERG (p = 0.1441) or KCNQ1 (p = 0.6671).