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Table 3 Average chemical differences of amino acid changes

From: Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations

Gene

Disease

nsSNP

Interspecific

HERG

93.63 (3.99)

n = 172

75.50 (10.55)

n = 16

67.37 (1.97) *

n = 296

KCNQ1

88.29 (3.75)

n = 174

52.25 (8.66) †

n = 12

58.32 (2.74) *

n = 168

  1. *, † indicate a significant difference from disease severity († p < 0.0001, *p < 0.008) as determined by a Mann-Whitney U test. There was no significant difference between the average chemical differences observed in disease vs. polymorphic changes (p = 0.218) for HERG. There was no significant difference between the average chemical differences observed in polymorphic and interspecific amino acid changes in either HERG (p = 0.1441) or KCNQ1 (p = 0.6671).