Figure 2

Phylogenetic relationships between medaka NITR V and I domains. (a – left panel) Neighbor-joining tree of V domains encoded by 44 medaka NITR genes. NITR numbering corresponds to Figure 1. Bootstrap values are assigned to each interior branch. Bootstrap values less than 60 are not shown. Branch lengths correspond to the number of amino acid substitutions estimated by Poisson correction; scale indicated below. Color-coding (below) corresponds to chromosomal placement; white is used if locus is not assigned. (right panel) Generalized genomic organization of NITRs shown in left panel (summarized from Figure 1, not to scale). Rectangles correspond to exons (L = leader; V = variable Ig domain; I = intermediate Ig domain; TM = transmembrane domain; C1 and C2 = cytoplasmic domain). Predicted but unidentifiable exons are indicated in parentheses. (b – left panel) A neighbor-joining tree of I domains encoded by 36 medaka NITR genes. (right panel) Generalized genomic organization of NITRs shown in left panel (summarized from Figure 1, not to scale). Annotation as in (a).