Figure 6

Physical maps showing the organization of the human C2H2-ZNF genes from cluster 19.12 localized on 19q13.4 and its syntenically homologous counterparts in other mammals. For the large C2H2-ZNF cluster 19.12 and its syntenically homologous counterparts in chimpanzee, mouse, rat and dog, each C2H2-ZNF gene is represented by an open arrow which indicates its orientation on the chromosome strands (this excludes the pseudogenes whose names appear in parenthesis). The presence of a conserved N-terminal KRAB domain is indicated by a square positioned in front of the open arrow representing the gene. Genes identified as orthologs, based on the phylogenetic tree and physical maps, are underlined and are aligned vertically on their respective chromosomes. Dotted lines separate the genes belonging to Group I, Group II and Group III defined in the phylogenetic tree (Figure 5). The two species-specific groups from dog and primates are seen in Group I and Group II, respectively.