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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Evolution of the CDKN1C-KCNQ1 imprinted domain

Figure 4

The KCNQ1 region in human, tammar, mouse and chicken. Exons 1a/b to 15 are shown as vertical lines and intronic distances by horizontal lines. The KCNQ1OT1 transcript (blue line) is transcribed from a promoter within the maternally methylated CpG island (red box with pink lollipops). A multiple PIP alignment of mouse, tammar and chicken against human KCNQ1 (A.). Conserved (red) and homologous regions (green) are common between mouse and human, especially in intron 10 (spanning the majority of KCNQ1OT1). Both tammar and chicken are divergent from human (divergence indicated by white) in this, and other intronic regions, with only exons showing high homology. The exon-intron structure of human and tammar is highly conserved, with the notable exception of intron 9, which is markedly reduced in the tammar (B). Human, mouse and chicken have at least one CpG island in the KCNQ1 region, while tammar has no CpG islands. There is a notable reduction in the number of repetitive elements in chicken compared to the mammalian species. DNA elements (pink), LTR elements (purple), simple repeats (green) and non-LTR (LINE/SINEs, blue). A conserved region of highly repetitive sequence in mouse and human in intron 9 is indicated by a red dashed box.

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