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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Evolution of the CDKN1C-KCNQ1 imprinted domain

Figure 1

Immunohistochemical localisation of p57KIP2 in the tammar yolk sac. Haematoxylin and eosin stained bilaminar yolk sac (BYS, A.) and trilaminar yolk sac (TYS, B.) showing trophoblast cells (Tr), yolk sac endodermal cells (En), and, in the trilaminar yolk sac only, mesenchymal cells (Me) and vitelline vessels (VV). The trophoblast lies adjacent to the maternal endometrium (Endo). p57KIP2 was found in the cytoplasm and nucleus of most trophoblast and endodermal cells in the bilaminar (C.) and trilaminar (D.) yolk sac placenta. Although mesenchymal cells were also stained, fewer were positive. IgG antibody controls also showed weak cytoplasmic, but not nuclear staining (bilaminar, E; trilaminar, F). Day 25 of gestation stages are shown, but staining did not change notably over the stages examined (Days 19 to 26).

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