Skip to main content
Figure 1 | BMC Evolutionary Biology

Figure 1

From: Experimental manipulation of immune-mediated disease and its fitness costs for rodent malaria parasites

Figure 1

Effect of IL-10R blockade on the extent decreased survival time depended on P. c. chabaudi parasite genotype. C57BL/6J mice were administered neutralizing αIL-10R mAb or control IgG, 1 day before and on days 1, 2, 3 and 4 post infection with 106 parasites of one of eight distinct P. c. chabaudi clones (CW, AS, AD, AQ, BC, AJ, AT or ER). Each pie-chart symbol represents the proportion of mice surviving until day 21 (white fill), while the position of the pie-chart along the y-axis indicates mean time to death in that treatment group (based on the mean of five mice ± S.E.). Day 21 was chosen as the end-point, to ensure that the acute phase of malaria infection was captured. Thus a mean of 21 without variance and with solid white fill indicates no mice died from that treatment group. Relative to control mice, αIL-10R treated mice suffered a higher mortality rate (~15% versus ~100%, respectively) and a quicker time to death (average time to death: 18.1 +/- 0.1 versus 7.5+/-0.2 days, respectively) and normally avirulent P. c. chabaudi clones were brought to lethality when IL-10R was blocked.

Back to article page