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Table 1 Diversity of non-plant FH2 proteins

From: Roots of angiosperm formins: The evolutionary history of plant FH2 domain-containing proteins

Kingdom Phylum FH1 GBD/FH3 DAD PH C2 PDZ PTEN tm Other
Animalia Chordata + + + - - + - - -
  Nematoda + + - - - - - + -
  Annelida + + + - - + - + -
  Mollusca + + + - - + - - -
  Insecta + + + - - - - - -
  Crustacea + + + - - - - - -
  Choanoflagellata + + - + - - - - -
Fungi Ascomycota + + - - - - - - -
  Basidiomycota + + - - - - - - -
  Zygomycota + + - - - - - - -
Amoebozoa Dictyostelida + + - - + - - - -
  Entamoebidae + + - - - - - - -
Chromalveolata Apicomplexa + - - - - - - - -
  Ciliophora + + - - - - - - ARM
  Stramenopila + + - + + - + - ANK, WW
Excavata Kinetoplastida + - - - - - - - -
  Parabasalia + + - - - - - - -
  Heterolobosea + + - - - - - + -
Plantae See Table 2 + - - - - - + + RhoGAP
  1. An overview of conserved domains and motifs in non-plant FH2 proteins. For each group of organisms, presence or absence of conserved domains or motifs found in formins of at least two species is indicated (if found in at least two proteins of only one lineage, they are listed as "other"); for more detailed table including single-instance domains, a full list of species and numbers of genes see Additional file 4. Domain abbreviations and accessions are: FH1 – formin homology 1 (a polyproline stretch detected visually), GBD/FH3 – GTPase binding domain of Diaphanous-related formins [Pfam: Drf_GBD] and/or FH3 domain of Diaphanous-related formins [Pfam: Drf_FH3], DAD – Diaphanous autoinhibitory domain [Pfam: Drf_DAD]; PH – pleckstrin homology domain [Smart: SM00233], ANK – ankyrin repeats [Smart: SM00248], C2 – protein kinase C conserved region 2 [Smart: SM00239], PDZ – domain present in PSD-95, Dlg, and ZO-1/2 [Smart: SM00228]; PTEN – phosphatase and tensin homology domain (identified by BLAST), tm – a secretion signal/transmembrane helix combination.