Reducing the false positive rate in the non-parametric analysis of molecular coevolution

Table 4 Coevolution analysis in the env protein of the Human Immunodeficiency Type 1 virus HIV-1.

Group of coevolution	Amino acid sites^a	Mean H(X)^b	Mean H(Y)^c	Mean H(X, Y)^d	Mean MI^e
G1	L21, S640, L641, T723	0.5560	0.5527	0.8858	0.2228
G2	L21, S640, V833	0.5391	0.5510	0.8858	0.1926
G3	T232, S640, L641	0.5930	0.6066	0.8858	0.2385

^a Amino acid sites included in each coevolution group. All sites within the same group coevolve between each other. Numbers indicate the position of the site taking as reference the sequence of Saccharomyces cerevisae.
^b Measure of mean uncertainty for the first site of the coevolving pair.
^c Measure of mean uncertainty for the second site of the coevolving pair.
^d Measure of the mean joined uncertainty for the pairs of sites within each group
^e Mutual Information mean value for all the possible coevolving pairs within the group.

ISSN: 2730-7182