Table 1 Amino acid sites in Escherichia coli detected to be important for the function of GroEL.
From: Reducing the false positive rate in the non-parametric analysis of molecular coevolution
Amino acid site | Function Description | Literature |
|---|---|---|
30–33, 51–53, 87–91, 150–151, 398, 414–416, 454, 478–481, 493, 495 | ATP/ADP and Mg2+ binding residues (ATP/Mg-B) | [48] |
199, 201, 203–204, 234, 237, 259, 263–264 | Substrate binding (SubB) | [48] |
230, 238, 241, 257, 260, 261, 265, 268, 270, 271 | Substrate binding(SubB) | [49] |
234, 237, 238, 241, 242, 257, 261, 265, 270 | GroES binding (ESB) | [48] |
241, 257, 261, 265, 270 | GroES binding (ESB) | [49] |
4, 41–42, 58–59, 61, 63, 75–76, 80, 83, 178–179, 188, 196–197, 224–226, 252, 253, 255, 257, 277, 283, 286, 303, 304, 308, 327, 328, 359, 361, 363, 364, 367, 368, 371, 380, 386, 390, 393, 397, 404, 408, 523 | Charged residues exposed to the central cavity in the cis ring, probably contacting substrates (CER) | [50] |