Figure 4
From: Reducing the false positive rate in the non-parametric analysis of molecular coevolution
Testing the effect of different parameters in the percentage of positive values (PPV, plots a to c) and sensitivity (SN, plots d to f) of Mutual Information Criterion based methods to detect coevolution when filtering by the correlation in hydrophobicity is applied. We tested the effect on PPV and SN of variations in the size of the multiple sequences alignment (MSAs, with the sizes ranging between 20 and 100 sequences), mean pairwise amino acid distance (with distances ranging between 0.1 and 2 amino acid substitutions per site) and strength of coevolution (the level of coevolution ranged between a minimum of 10% and a maximum of 25%).