From: Evolution of pharmacologic specificity in the pregnane X receptor
Cmp. # | Compound | hPXR Activity | hPXR Efficacy | zfPXR Activity | zfPXR Efficacy | Toxicity |
---|---|---|---|---|---|---|
MI1 | Acetaminophen | None | Â | None | Â | None |
MI2 | 3-Aminobenzoic acid | None | Â | None | Â | None |
MI3 | Benzo [a]pyren | 4.75 | 0.55 | 4.00 | 0.06 | 100 |
MI4 | n-Butyl-4-aminobenzoate | 4.88 | 1.35 | 4.86 | 0.69 | 100 |
MI5 | Butylbenzoate | None | Â | None | Â | None |
MI6 | Caffeine | None | Â | None | Â | None |
MI7 | Carbamazepine | 4.20 | 0.37 | None | Â | 200 |
MI8 | Carbamazepine epoxide | 4.09 | 0.57 | None | Â | 200 |
MI9 | β-Carotene | 5.46 | 0.67 | None |  | 100 |
MI10 | Chlorpyrifos | 4.59 | 2.05 | 5.44 | 0.88 | None |
MI11 | Chlorzoxazone | None | Â | None | Â | 500 |
MI12 | Cyclosporine | None | Â | None | Â | 20 |
MI13 | Ecdysone | None | Â | None | Â | None |
MI14 | Ethyl-2-aminobenzoate | None | Â | None | Â | None |
MI15 | Flurbiprofen | 4.10 | 1.59 | 4.10 | 0.53 | None |
MI16 | Folic acid | None | Â | None | Â | None |
MI17 | Guggulsterone | None | Â | None | Â | None |
MI18 | GW3965 | None | Â | None | Â | 10 |
MI19 | Hyperforin | 7.22 | 1.29 | None | Â | 50 |
MI20 | Mevastatin | 5.23 | 0.51 | None | Â | 15 |
MI21 | Mycophenolic acid | None | Â | None | Â | None |
MI22 | Nifedipine | 5.33 | 0.41 | 4.91 | 0.99 | 50 |
MI23 | Oxcarbazepine | 4.74 | 0.35 | ~4.70 | ~0.30 | 200 |
MI24 | Paclitaxel | 4.92 | 0.13 | None | Â | 100 |
MI25 | Phenobarbital | 3.43 | 1.19 | 3.49 | 0.10 | None |
MI26 | Phenytoin | 4.26 | 0.52 | None | Â | 200 |
MI27 | n-Propyl-4-hydroxybenzoate | 4.51 | 0.32 | 4.28 | 0.31 | 100 |
MI28 | Provitamin D3 | None | Â | None | Â | 10 |
MI29 | Provitamin D2 | None | Â | None | Â | 20 |
MI30 | Reserpine | 4.91 | 0.72 | None | Â | 50 |
MI31 | Retinol | 5.80 | 0.20 | None | Â | 50 |
MI32 | Rifampicin | 7.00 | 1.00 | None | Â | 200 |
MI33 | SR12813 | 6.41 | 0.90 | None | Â | 10 |
MI34 | TCDD | 7.17 | 1.78 | 6.32 | 6.17 | 10 |
MI35 | TCPOBOP | 5.25 | 0.66 | None | Â | 200 |
MI36 | T-0901317 | 7.66 | 1.24 | None | Â | 100 |
MI37 | α-Tocopherol | ~4.30 | ~0.25 | None |  | 100 |
MI38 | β-Tocopherol | 4.85 | 0.33 | None |  | 100 |
MI39 | δ-Tocopherol | 5.14 | 0.64 | None |  | 100 |
MI40 | γ-Tocopherol | None |  | None |  | 100 |
MI41 | 1α,25-Dihydroxyvitamin D3 | None |  | None |  | 50 |
MI42 | 1α-Hydroxyvitamin D2 | None |  | None |  | 50 |
MI43 | 1α-Hydroxyvitamin D3 | None |  | None |  | 50 |
MI44 | Vitamin K1 | 4.99 | 0.13 | None | Â | 100 |
MI45 | Vitamin K2 | 5.04 | 0.80 | None | Â | 100 |
MI46 | Vitamin K3 | ~4.30 | ~0.15 | None | Â | 100 |