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Figure 7 | BMC Evolutionary Biology

Figure 7

From: Modeling HIV quasispecies evolutionary dynamics

Figure 7

CD4+ T-cells concentration during HIV-1 super-infection. CD4+ T-cells concentration during HIV-1 super-infection by a R5 viral strain. Different signs represent: evolution without superinfection, (ā—‡); superinfection occurring at time t = 100 and 400, (+) and (ā–”), respectively. For a superinfection event occurring after the R5 to X4 switching the dynamics is qualitatively the same as for a single infection, (ā—‡). If the second delayed infection occurs before the R5 to X4 switching, the time of appearance of X4 viruses may be shorter, when the superinfecting strain is closer to the X4 phenotypes, (+, ā–”). Parameters as in Figure 6.

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