In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae

Table 1 Functional divergence type I analysis between GroEL protein paralogs in Chlamydiae species.

Comparison	θ^a ± SE(θ)	α^b	LRT^c	P(LRT)
GroEL1 vs GroEL2	0.371 ± 0.096	1.834	15.025	< 0.001
GroEL1 vs GroEL3	0.943 ± 0.099	1.921	90.978	<< 0.001
GroEL1 vs GroEL2-3	0.414 ± 0.117	3.448	12.484	< 0.001
GroEL2 vs GroEL3	0.441 ± 0.073	3.105	36.014	<< 0.001

^a The coefficient of Functional divergence type I calculated by maximum likelihood.
^b The shape parameter of the Gamma distribution of substitution rates among sites.
^c The likelihood ratio test to compare the likelihood of the hypothesis indicating no functional divergence to the hypothesis assuming functional divergence. LRT has been approached to a χ² distribution with 1 degree of freedom.

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