Figure 7
From: Evolution of pigment synthesis pathways by gene and genome duplication in fish
Evolution of sepiapterin reductase genes in vertebrates. (a) Maximum-likelihood phylogeny of Spr protein sequences based on 313 AA positions. The tree is rooted with Spr from fruitfly. Numbers at the branches denote bootstrap values (maximum likelihood/neighbor joining) above 50%. Groups are assigned according to synteny. (b) Synteny of spr regions in vertebrates. The human SPR region is syntenic to two spr paralogons in Takifugu (Tru), stickleback (Gac) and zebrafish (Dre). sprb was possibly lost in Tetraodon (Tni) and medaka (Ola). Numbered bars represent genes contributing to conserved synteny, genes that do not contribute to conserved synteny are not shown. Blue indicates genes that are duplicated along with spr. Dotted lines connect orthologous genes.