Figure 8

Intron placement with respect to coding sequences for conserved structural elements. Intron placement is indicated by vertical bars in the rows above the structural model for each crown group of organisms (see Fig. 4 for symbol descriptions). The positions of the GLK motif (triangles), the VDAC motifs identified in this study (stippled boxes) and the eukaryotic signature motif (open boxes) are indicated below the structural models. Note that the fungal VDAC motif is formed by two sequence elements; the intervening region is shown as a dotted line. Patterns of intron location that are found in several VDAC genes are shown only once. Animal sequences. Hs, Homo sapiens VDAC1 (NP_003365) and VDAC3 (NP_005653); Rn, Rattus norvegicus VDAC1 (NP_112643) and VDAC3 (NP_112645); Gg, Gallus gallus VDAC1 (TC10222), VDAC2 (NM_204741), VDAC3 (TC9741); Dr, Danio rerio accession numbers NM_199585 and BC065468; Hs2, H. sapiens VDAC2 (NP_003366), Rn2, R. norvegicus VDAC2 (NP_112644); Dm, Drosophila melanogaster VDAC1 (CG6647-PA), VDAC2 (NP_609462), and isoform B of CG31722 (AAF53018); Dm-2; D. melanogaster isoform A (AAF53019); Sp, Strongylocentrotus purpuratus (sea urchin, XM_775173); Ag, Anopheles gambiae (XM_318947). Middle panel: Fungal sequences. Cn, Cryptococcus neoformans (XM_569804.1); Nc, Neurospora crassa (XP_323644). Lower panel: Plant sequences. At, Arabidopsis thaliana, (NP_186777, NP_201551, NP_200057, NP_197013); At-2 A. thaliana (NP_190561); Os-1, Oryza sativa (CAB82853); Os-2, O. sativa (CAC80850); Os-3, O. sativa (CAC80851).