Figure 6

Comparison of animal mitochondrial porin gene structures. The exonic and intronic regions of mitochondrial porin open reading frames were mapped for a variety of organisms. The gene structure for all species was retrieved from the NCBI genome database using BLASTN or map viewer programs to analyze the ORF of each porin cDNA. Data were derived from the sequences described in the legend to Figure 8. Only regions of the gene containing ORFs are shown; chromosome number is indicated beside the species in Roman numerals and plus (+) or minus (-) strand reading frames are indicated beside chromosome number. Where multiple spliceoforms exist, as for human VDAC2, the form not listed as a splice variant was used. Lengths of exons in bp are indicated inside the boxes representing the exons; the numbers of the corresponding amino acid residues are indicated below the boxes. Lines indicate introns, the sizes of which are indicated in kb above the line; the intron phase (0, 1, or 2) is indicated directly above the intron size. Phase 0 introns do not interrupt codons, whereas phase 1 and phase 2 introns are positioned after the first and second nucleotides of the codon, respectively. The positions of the coding sequence for the GLK (diamonds) and the eukaryotic porin (circles) motifs are shown above the intron/exon map. Filled and open symbols indicate matches and imperfect matches to these motifs, respectively.