Figure 2

Composition, evolutionary conservation and general structure of tethering complexes. The individual subunits of each of the complexes are shown as ovals, arranged according to interaction data from many sources (including pull down, yeast two hybrid, direct structural visualisation and genetic data). For clarity, not all interactions are shown. For example, there is evidence to support interactions between COG 1 and COGs 3 and 4 and additional interactions within the exocyst complex. Individual subunits are colour-coded for evolutionary conservation; red designates a subunit that has wide taxon distribution, whilst subunits in green are absent from multiple taxa. Interactions with factors outside of the tethering complex are indicated in black – the line indicates the approximate interaction interface, if known. See Figure 4 and additional file 3 and the text for full details.