Figure 1

Location and functions of multi-subunit tethering complexes and SM proteins in an idealised eukaryotic cell. A generalised endomembrane system with only the major trafficking routes is shown, including the multiple recycling pathways that intersect with the Golgi complex and various endosomal subcompartments. The locations of tethering complexes discussed in this article are shown in red and of SM proteins in green. Note that the precise location is not always clear, for example the HOPS complex is known to function in late endocytic steps, but the functional and physical subdivision of the late endosomal population is not precise. Further, some factors may function in more than one locale. The figure is based on Figure 1 from Morgan et al., [64] with the permission of the authors.