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Table 5 Correlation analysis results for the MAP data set.

From: Detecting groups of coevolving positions in a molecule: a clustering approach

PDB Size Weight Stat. Nmin p-value FDR 3D dist. 3D p-value
ARG147, ASP187 2 Unweighted 0.57 4.92 0*** yes 6.24 0.001***
ARG147, ASP187 2 Grantham 0.59 517.54 0*** yes 6.24 0.001***
ARG147, ASP187 2 Volume 0.58 384.76 3e-04*** yes 6.24 0.001***
GLN154, GLU158 2 Unweighted 0.65 4.93 0*** yes 5.96 0.001***‡
GLN154, GLU158 2 Charge 0.67 4.1 1e-04*** yes 5.96 0.001***‡
GLY122, LEU230 2 Unweighted 0.6 6.42 1e-04*** yes 7.44 0.002**‡
GLY122, LEU230 2 Grantham 0.6 590.32 1e-04*** yes 7.44 0.002**‡
GLY122, LEU230 2 Polarity 0.61 18.34 1e-04*** yes 7.44 0.002**‡
GLY122, LEU230 2 Volume 0.48 275.16 0.0052** yes 7.44 0.002**‡
ALA21, LEU25, GLY107 3 Unweighted 0.45 4.09 1e-04*** yes 12.07 0.001***
LEU25, GLY107 2 Grantham 0.52 312.81 0.0077** no 12.07 0.031*
THR241, GLY244 2 Unweighted 0.57 3.24 3e-04*** yes 5.11 0.001***
ASN46, SER68 2 Unweighted 0.48 4.67 5e-04*** yes 5.92 0.001***
GLY210, THR225 2 Unweighted 0.56 3.25 5e-04*** yes 8.28 0.004**
ASP219, TRP221, THR222, THR225, ASP227, GLU235, ILE238, THR241, LEU248 9 Grantham 0.3 68.81 6e-04*** yes 40.12 0.2338†
TRP221, THR222 2 Unweighted 0.57 2.73 0.0014** yes 3.75 0.001***†
TRP221, THR225, 3 Volume 0.56 105.03 0.0092** no 18.13 0.024*†
ASP227         
LEU125, THR129 2 Unweighted 0.53 3.21 6e-04*** yes 6.12 0.001***
ASN208, SER231 2 Unweighted 0.48 4.32 7e-04*** yes 4.25 0.001***
TRP221, THR222, ALA232, GLU235, ILE238, VAL239, THR241, ILE247, LEU248 9 Polarity 0.28 2.15 0.001*** yes 34.73 0.025*
GLU148, GLU190 2 Unweighted 0.48 5.11 0.0011** yes 11.88 0.03*
GLU148, GLU190 2 Polarity 0.5 13.91 0.006** yes 11.88 0.03*
GLY210, GLY244, GLU246 3 Grantham 0.43 302.15 0.0012** yes 33.45 0.4945
CYS78, ASN95, SER110, GLY150, GLN233 5 Unweighted 0.24 2.48 0.0018** yes 21.37 0.001***
CYS169, GLN182 2 Unweighted 0.45 4.39 0.0018** yes 6.4 0.002**
ILE96, TYR134 2 Unweighted 0.49 5.96 0.002** yes 18.27 0.1768
ILE81, PHE113 2 Unweighted 0.45 4.33 0.0021** yes 16.36 0.1259
ASP227, ALA232, GLU235 3 Unweighted 0.48 1.41 0.0022** yes 23.49 0.0949.
ASP219, VAL223 2 Unweighted 0.46 3.66 0.0024** yes 9.4 0.009**
HIS63, ARG127, GLN130, ALA209 4 Volume 0.33 205.12 0.0032** yes 32.09 0.2527
HIS63, GLN130 2 Charge 0.47 5.36 0.0035** yes 28.75 0.5994
THR222, SER231, ILE238, VAL239 4 Charge 0.71 0.99 0.0039** yes 28.93 0.1199
ARG124, GLU131 2 Grantham 0.48 461.88 0.0043** yes 10.6 0.016*
GLU131, VAL157, VAL164 3 Unweighted 0.36 4.39 0.0045** yes 13.43 0.001***
GLN53, VAL98 2 Grantham 0.48 409.37 0.0049** yes 13.51 0.0579.
GLU29, VAL32, ILE81, PRO82, THR129, ALA136, ILE149, GLY150, SER163 9 Polarity 0.21 0.1 0.005** yes 32.31 0.008**
LEU135, PHE156 2 Grantham 0.49 575.88 0.0052** yes 8.71 0.004**
GLN53, GLU160 2 Charge 0.44 5.85 0.0055** yes 39.55 0.9311
VAL56, ILE101 2 Unweighted 0.51 6.53 0.0062** yes 5.28 0.001***
VAL56, ILE101 2 Grantham 0.47 457.69 0.0069** no 5.28 0.001***
LYS117, GLU123, ARG127 3 Grantham 0.4 487.3 0.0076** no 15.43 0.004**
PRO118, THR119 2 Polarity 0.47 18.47 0.0096** no 3.75 0.001***
ALA232, TYR234, GLU235 3 Charge 0.87 1.41 0.0098** yes 10.51 0.002**
  1. Legends are the same as in table 1. Only groups with a p-value lower than 1% are reported. A global false discovery rate (FDR) of 1% was used when correcting for multiple testing.