Skip to main content

Table 1 Correlation analysis results for the myoglobin data set.

From: Detecting groups of coevolving positions in a molecule: a clustering approach

PDB Size Weight Stat. Nmin p-value FDR 3D dist. 3D p-value
THR39, GLY65, LEU76, GLU148 4 Volume 1 26.62 0.0044** yes 28.21 0.1688†
THR39, GLY65, LEU76 3 Unweighted 1 0.98 0.0136* yes 23.64 0.1409†
LEU11, ALA94, ILE111, ARG118, GLY150 5 Grantham 0.87 78.46 0.0045** yes 38.14 0.7023†
LEU11, ALA94, ARG118, GLY150 4 Polarity 0.96 2.55 0.0065** yes 38.14 0.8252†
LEU11, ALA94, ILE111, MET131, LEU135, LEU149, GLY150 7 Volume 0.82 20.89 0.007** yes 33.1 0.1668†
GLY5, GLY23, GLU52, GLN91 4 Unweighted 0.47 2.67 0.0148* yes 37.62 0.7952
LYS56, TYR103 2 Volume 0.96 84.01 0.0189* yes 21.25 0.3506
ARG31, SER117 2 Volume 0.75 137.41 0.0241* yes 11.89 0.023*‡
SER58, GLU85 2 Unweighted 0.72 1.9 0.0245* yes 28.12 0.6853
ALA15, LYS63, ALA84, GLU85, GLN91 5 Grantham 0.5 133.99 0.032* yes 27.7 0.0819.
ALA15, LEU61, ALA84 3 Unweighted 0.53 2.27 0.0346* no 26.43 0.2817
ASP20, PHE33, LEU69, THR95 4 Volume 0.97 20.99 0.0347* yes 31.15 0.3197†
PHE33, LEU69 2 Unweighted 1 1 0.0347* no 16.14 0.1309‡
GLY121, ASP122 2 Unweighted 0.6 3.55 0.0379* no 3.63 0.001***
ASP20, GLY23, ASP60, LYS63, ALA84, GLU85, LYS96 7 Charge 0.46 0.99 0.0379* yes 29.33 0.035*†
GLU105, GLU136 2 Unweighted 0.74 1.77 0.0444* no 8.25 0.003**
TRP7, LYS47, LYS62 3 Volume 0.71 87.27 0.045* yes 35.94 0.8052
  1. 3D dist.: maximum pairwise 3D distance between alpha carbons (Å). 3D p-value: test if the sites are closer than expected by chance. FDR: tell if the group remains significant after a correction for having a global false discovery rate of 5%. ‡ symbols indicate groups detected by both the correlation and compensation analyses, † symbols indicate groups overlapping with a detected group in the compensation analysis (i.e. one group is a sub-group of the other).