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Table 3 Z-scores of free energy. Comparison between each real pre-miRNA and 1,000 random and four types of shuffled sequences.

From: In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Species

Random

Zero-markov

Mononucleotide

First-markov

Dinucleotide

H. sapiens

-3.96 ± 1.27

-4.31 ± 1.40

-4.36 ± 1.40

-6.05 ± 1.85

-5.63 ± 1.87

C. elegans

-2.51 ± 1.52

-3.34 ± 1.45

-3.37 ± 1.46

-4.85 ± 2.18

-4.87 ± 2.09

D. melanogaster

-2.30 ± 1.05

-3.53 ± 1.08

-3.53 ± 1.08

-4.83 ± 1.51

-4.85 ± 1.56

D. rerio

-2.87 ± 1.33

-3.53 ± 1.19

-3.64 ± 1.23

-4.91 ± 1.69

-4.67 ± 1.64

M. musculus

-3.63 ± 1.25

-3.89 ± 1.40

-3.87 ± 1.34

-5.41 ± 1.83

-4.95 ± 1.84

R. norvegicus

-3.68 ± 1.33

-3.60 ± 1.30

-3.68 ± 1.33

-5.25 ± 1.80

-4.80 ± 1.86

Average

-3.26 ± 1.42

-3.75 ± 1.35

-3.81 ± 1.35

-5.28 ± 1.86

-4.98 ± 1.83