Genomic arrangement of the human extended Leukocyte Receptor Complex and syntenic relationship of the CEACAM and PSG loci in human, mouse and dog. (A) The location and size of the genomic regions on human chromosome 19q13 containing genes for immune adaptor proteins, CEACAM/PSGs, SIGLEC proteins and the Leukocyte Receptor Complex are indicated by colored bars. (B) Genomic organization of mouse, dog and human CEA gene family loci. Arrowheads represent genes with their transcriptional orientation. CEACAM genes are shown in yellow, PSG genes in red, SIGLEC genes in blue and marker genes in black. The scale indicated by dots is 1 Mbp unless interrupted by slanted lines. The following Ensembl/NCBI releases were used: mouse, NCBIm36; dog, CanFam 1.0, WGS database; human, NCBI 36. Nucleotide numbering of the chromosomes starts at the centromere. Note the inverse orientation of the human chromosome 19 region. CC/Cc, CEACAM/Ceacam; chr, chromosome.