Figure 6

Identification of highly conserved residues of p40 phox. (A) A schematic structure of p40phox domains is shown; proline-basic region, P-basic. Abbreviations of domain names are described in legends to other Figures. Letters in gray boxes indicate highly conserved proline and basic amino acid residues in the P-basic region. Letters in solid boxes indicate key acidic residues of OPCA motif that have been demonstrated by X-ray crystallographic structure [32]. K355 and K382 indicate two residues of human p67phox that interact with the OPCA motif. (B) Molecular taxonomy was generated by the alignment of amino acid sequences of PX domain. Species name abbreviations are given in Figure 3.