Figure 11
From: Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes
Predicted binding partners of fungal NOXR and activation models of fungal Nox. (A) A hypothetical domain structure of a predicted NOXR partner is shown. (B) Domain structures of fungal proteins with PB1 domains meeting criteria for possible NOXR-partners are shown, along with their GenBank™ accession numbers. Abbreviations: An, A. nidulans; Mg, M. grisea; Fg, F. graminearum. (C) Aligned OPCA motifs of candidate NOXR partners are compared with the corresponding region in p40phox and the yeast isolog (the first and second alignments). Amino acid residues conserved among fungal ortholog sequences are indicated by asterisks. (D) A proposed model for activation of fungal Nox by NOXR and Bem1 protein. (E) A proposed model for activation of fungal Nox by NOXR and Cdc24. (F) A proposed model for activation of fungal Nox by CBSn-PB1 proteins. RhoGEF, Rho guanine nucleotide exchange factor; CBS, cystathionine beta-synthase; Abbreviations of other domain names are described in legends to other Figures.