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Figure 10 | BMC Evolutionary Biology

Figure 10

From: Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Figure 10

Evolution of a vast family of p47 phox proteins. (A) Molecular taxonomy of the p47phox and related proteins is shown. The sequences of SH3PXD2 orthologs are provided in Additional file 10. Predicted domains structures of H. sapiens (p47phox, NOXO1, SH3PXD2a, 2b) and M. brevicollis (p47phox-like) proteins are shown near to each subfamily: P, proline-rich region; C, C-tail region. An asterisk indicates the appearance of a C. intestinalis SH3PXD2 branch from a common root of the p47phox-like protein. Abbreviations of species names and other domains are given in other Figures. (B) A schematic drawing to show a hypothetical evolution of an expanded p47phox-like gene family. Branches are for illustrative purposes and are not proportional to rates of divergence.

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