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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Figure 1

Relationships between the phylogenic tree of species and the occurrence of Phox -reated regulatory subunits. (A) Summary of the occurrence of Nox-regulatory subunit genes in vertebrates, a urochordate, an echinoderm, fungi, and a slime mold amoeba are shown. Asterisks indicate that the gene is a co-ortholog ancestor of all members of the vertebrate Nox1-3 subgroup. Superscripted letters represent: (a), a partial amino acid sequence predicted from genomic DNA fragment (nucleotides 713622–713565 of GenBank™ No. NW_001471438.1), (b) the gene taxonomy is discussed in the text. (B) Summary of the occurrence of Nox-regulatory subunit genes within Deuterostomia. The number in the fork of each branch indicates the estimated time in millions of years (Mya, millions of years ago) since a given species diverged. A schematic phylogeny and the estimated time of occurrence of species were created from genomic information [62, 125]. Branch lengths are for illustrative purposes and are not proportional to time since divergence.

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