Figure 2

Structural model of the V1a receptor with amino acid substitutions in the genus Microtus. AA substitutions are spread over the whole protein, but largest numbers of changes are found in the functionally important ligand binding domain. Position of changes and type of changes are marked as: black circle = radical change; white circle = conservative change; grey circle = conservative and radical changes at the same position; white square = deletion; black square = insertion; black triangle = radical change and deletion at the same position. Changes between protein types within an individual occur in the functionally important regions (ligand and G-protein binding domains) and are marked as red diamond for a radical change, and as orange diamond for a conservative change.