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Table 1 Genes in epipolythiodioxopiperazines (ETP) biosynthetic gene clusters

From: Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes

Gene

Best match

P

Non-ribosomal peptide synthetase

T

Thioredoxin reductase

C

Cytochrome P450 monooxygenase

I

Aminocyclopropane carboxylic acid synthase (ACCS)

J

Dipeptidase domain.

M

O-Methyl transferase domain.

G

Glutathione S-transferase domain.

N

Methyl transferase domain

A

Transporter

Z

Zinc binuclear cluster (Zn(II)2Cys6) regulator

D

Prenyl transferase

O

Aldehyde reductase

E

Cytochrome P450 monooxygenase

S

Progesterone 5-B reductase

B

Cytochrome P450 monooxygenase

R

Progesterone 5-B reductase

Q

Progesterone 5-B reductase

K

Hypothetical protein

F

Cytochrome P450 monooxygenase

H

Acetyl transferase

  1. Cluster genes predicted in the biosynthesis in sirodesmin PL and gliotoxin in Leptosphaeria maculans and Aspergillus fumigatus, respectively (P, T, C, I, J, M, G, N,), as well as transporter (A) and transcriptional regulator (Z). Genes predicted to be involved in biosynthesis of side chains of these two ETPs are also listed (D, O, E, S, B, R, Q, K, F, H) [3, 4].